Treatment Rationale

As we scientifically show, ASD is the result of infection, inflammation and immune system aberration. Autistic behavior - is the symptom of neuroinflammation of viral origin. So, in order to treat the symptom, the underlying cause should be treated. 

 

Unfortunately, such a simple approach is not currently used. 

There have been many treatment approaches to the treatment proposed. 764 parents of ASD children were interviewed about the types of treatments that had been prescribed for their children in a study, and the results revealed that 111 types of treatment had been used.

The most common were interventional corrective therapies including speech therapy, interventional and ABA therapies and nutritional supplement administrations

including vitamin B6, fatty acids and magnesium.

 

Medications were used less frequently. Among the most common medications were sleep aids and antipsychotic, antihypertensive and antidepressant drugs.

The effectiveness of these drugs and therapies was assessed by a meta-analysis of the existing clinical studies. Despite a variety of approaches, there was no therapy that produced significant improvements. It was therefore concluded that there is no effective comprehensive treatment for ASD children.

However, when we tried the etiotropic approach (meaning that we targeted the underlying cause with the treatment), we found out that there is in fact a protocol that delivers positive change.

The protocol we utilize is a combination of 1 Rx antiviral drug, Valacyclovir 

and 5 OTC ingredients: L-lysine, Elderberry extract, Astragalus extract, Olive leaf extract, and probiotic BC-30.

Valacyclovir

Valacyclovir is an antiviral ingredient. Compared to Acyclovir, it has a higher bioavailability—55% which is 2-4 times higher than the bioavailability of Acyclovir. 

Valacyclovir was reported to be effective in the inhibition of herpes viruses: HHV-1, HHV-2, HHV-3/VZVHHV-4/EBV, and HHV-5/CMV. In a clinical study, it was shown that Valacyclovir was both effective against the Epstein-Barr virus and well tolerated by children. The only side effects, which appeared in a small number of children, were a headache in 8%, and gastrointestinal disturbances in 16%.

 

Many additional studies demonstrated that Valacyclovir is well-tolerated by children and rare side reactions included only headache and diarrhea with no serious adverse effects. Valacyclovir is recommended for the treatment of herpetic infections in children by regulatory agencies of Central Asia, Eastern European countries and the USA.

L-lysine

L-lysine is an amino acid that is essential to the human organism. Usually, L-lysine is obtained from diet: from casein, phosphoprotein which is contained in dairy products. The importance of L-lysine for the human organism is in the fact that it participates in such processes as proper growth, muscle protein building, and metabolism.

L-lysine has been reported to inhibit herpes simplex virus by reducing the cytopathogenicity of the HHV-1. The study by Griffith et al.  demonstrated that patients who took L-lysine for 6 months had 2.4 times fewer cases of HHV-1 infection than patients in the placebo-controlled group. L-lysine, as well as other components of the protocol, does not cause any toxic or side effects. Additionally, this amino acid may be effective against such conditions as anxiety, mood disturbances, and headaches, which are very common for children with ASD.

Elderberry Extract

Elderberry extract in a nutritional supplement extracted from the black elder (Sambucus nigra L.). It has been used for many years in folk medicine because of its effectiveness against viruses, headache, and constipation. It has antiviral, anti-inflammatory, immunomodulatory and antioxidant activity.

 

In one of the studies, the effectiveness of elderberry against HHV-1 was described. In a clinical trial with 312 participants, it was shown that elderberry extract positively influences both physical and mental health. Furthermore, it was proven that there are no side or adverse effects to taking elderberry extract in any age groups including infants.

 

The effectiveness of the elderberry extract is due to cyanidin-3-glucoside and cyanidin-3-sambubioside flavonoids found in the plant, which modulate the immune system. Flavonoids are also known to have antioxidant and prooxidant activities of low-density lipoprotein. Anthocyanins which are a part of elderberry extract also possess anti-inflammatory properties.

Olive Leaf Extract

Olive leaf extract is also known as a part of folk medicine, and has been reported to have hypoglycemic, antioxidant, antiviral and antimicrobial effects. The presence of polyphenols and flavonoids in olive leaves helps provide this wide spectrum of properties.

 

A double-blinded placebo-controlled trial showed that olive leaf extract stimulates the downregulation of genes that participate in the inflammatory process (EGR1, COX-2, and ID3). 

 

 In another study, a significant reduction in the production of cytokines participating in the inflammatory processes as a result of olive leaf extract supplementation was demonstrated. Additionally, it was shown that olive leaf extract has antiviral and antioxidant activities.

 

For example, it decreased the viral infectivity of viral hemorrhagic septicaemia virus (VHSV) by 10-30%. Antioxidant activity due to the presence of functional compounds found in olive leaves’ flavonoids was also reported. Also among other plants, olive leaf extract and particularly biophenols contained in it can provide the highest neuroprotection (74%).

Astragalus Root Extract

Astragalus root extract is extracted from Astragalus membranaceus Moench herb, and as well as plants discussed above, was used for many years in folk medicine because of its ability to stimulate the immune system.

 

It was observed that astragalus root extract intake enhances the production of macrophages and lymphocytes. These cells are key actors of the immune system. Similar to olive leaves and elderberry, astragalus contains flavonoids that have a positive effect on the immune system. Moreover, astragalus extract can stimulate the growth of stem cells. The antiviral, anti-inflammatory and antibacterial activities of the extract were also shown.

 

Bacillus Coagulans Probiotic

Bacillus coagulans probiotic contains a high concentration of spores ensuring its long-term stability and efficacy in the gut. The main function of this probiotic is its ability to improve digestive health through activating more efficient digestive absorption and modulation of gut microbiota. It germinates in the small intestine and increases protein and carbohydrates absorption.

 

This property of probiotic is especially important for children with ASD since 70% were reported to have various problems of the gastrointestinal tract. It was demonstrated that probiotics intake positively influences children with ASD because it targets two problems at once, microbiota-gut-brain axis, through balancing microbiota, and it inhibits the toxic effect of some compounds on the brain which leads to a decrease in ASD symptoms.

 

Moreover, several studies indicated that Bacillus coagulans probiotic intake increases the immune response to viral agents. It was reported that Bacillus coagulans probiotic has the ability to inhibit 3 viruses of the herpes viruses group: HHV-1, HHV-2 and HHV-3. The toxicological assessment of Bacillus coagulans probiotic showed that the supplement has no toxic or other side effects.

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